Durham. It is a city in the U.S. state of North Carolina. It is located in Durham County. It is known for being the seat of Duke University. It is the fourth most populous city in the state, and its metropolitan area is inhabited by 451,212 people, according to the 2005 census.
It is located at coordinates 35 ° 59 ’19″N 78°54’26” W, at 123 msnm. According to the United States Census Bureau, the city has a total area of, of which, of it is land and of it. 245.1 km2 is land and 0.7 km2 (0.29%)is water.